Enfamil colic relief formula usually means Nutramigen with Probiotic LGG, a hypoallergenic powder that Enfamil says manages colic from cow's milk protein allergy. Parents also reach for Enfamil NeuroPro Gentlease, a gentler option for fussiness and gas in babies from birth to 12 months.

Enfamil states that Nutramigen can start easing colic from milk allergy in as little as 24 hours. Third-party guides put the typical window at 48 hours. Gentlease takes longer, usually three to five days, and suits milder fussiness.

This Enfamil colic relief formula review covers what each formula contains, how it works, what parents say, how it compares, safety, and price. Talk to your pediatrician before any switch, because colic has several possible causes.

What Is Enfamil Colic Relief Formula?

Enfamil colic relief formula is a family of infant formulas, led by Nutramigen with Probiotic LGG, that target colic and fussiness. The can carries a fast colic relief badge, a hypoallergenic label, and an 0 to 12 months age range. Enfamil does not sell one product with this exact name.

Two products cover the need. Nutramigen is the hypoallergenic pick for suspected cow's milk allergy. NeuroPro Gentlease is the lower-lactose pick for general gas, crying, and spit-up.

Here is the part most people miss. Colic means long bouts of crying in an otherwise healthy baby, and formula does not fix every case. A formula only helps when milk protein or lactose plays a role.

What Is Inside Nutramigen and Gentlease?

Nutramigen uses extensively hydrolyzed protein, which means the milk protein is broken into tiny pieces. It is lactose-free and adds the probiotic LGG plus DHA. Gentlease uses partially hydrolyzed protein with reduced lactose. Corn syrup solids replace some of the lactose.

Key features at a glance:

  • Nutramigen: extensively hydrolyzed protein, lactose-free, probiotic LGG, DHA
  • Gentlease: partially hydrolyzed protein, reduced lactose, prebiotic blend, DHA
  • Both: iron-fortified and made for babies from birth to 12 months

How Does Enfamil Colic Relief Formula Work?

Nutramigen works by breaking milk protein into pieces too small to trigger an allergic reaction. If a baby's colic comes from cow's milk protein allergy, the immune response calms down. Enfamil adds LGG, a probiotic it describes as the most studied for allergy management, to support gut and immune health.

Gentlease takes a softer route. Partial hydrolysis makes the protein easier to digest, and lower lactose eases gas. Does that sound like a smaller fix? It is, and for mild fussiness a smaller fix is often enough.

How most parents trial a new formula:

  1. Ask your pediatrician which formula fits your baby's symptoms.
  2. Switch fully to the new formula rather than mixing it with the old one.
  3. Track crying, gas, and stool for several days.
  4. Review results with your pediatrician after one to two weeks.

How Fast Does Enfamil Colic Relief Formula Work?

Enfamil claims Nutramigen relief can begin in 24 hours for colic due to cow's milk allergy. Other guides report improvement within 48 hours. Gentlease usually needs three to five days. Give any new formula one to two weeks before judging it.

What Are the Benefits of Enfamil Colic Relief Formula?

The main benefit is less crying and gas for babies whose colic traces back to milk protein or lactose. Parents on The Bump forums credit Gentlease with easing gas pain. Pediatric guides call Nutramigen a gold standard for allergy-linked colic.

Benefits parents and the brand mention:

  • Fast colic relief for cow's milk allergy cases
  • Lactose-free formula with Nutramigen
  • LGG probiotic for gut and immune support
  • Brain-building DHA
  • Gentler digestion with Gentlease
  • Wide availability online and in stores

Does Enfamil Colic Relief Formula Actually Reduce Crying?

Yes, for the right baby. Enfamil says Nutramigen is clinically shown to manage colic from cow's milk protein allergy. The catch? If milk protein is not the trigger, the result may be small. Many colicky babies have no allergy at all.

Does It Help With Gas and Spit-Up?

Gentlease targets exactly that. Enfamil positions it for fussiness, crying, gas, spit-up, and softer stools. Its partially hydrolyzed protein and prebiotic fiber blend support easier digestion. Babies with frequent spit-up may need a different type, so ask your pediatrician.

What Do Enfamil Colic Relief Formula Reviews Say?

Reviews are mostly positive, with the biggest praise going to fast calming and the biggest complaints going to price and smell. Parents describe weeks of painful crying that eased after a switch. A few babies show no change, which fits how varied colic is.

What Do Happy Parents Say?

One parent on The Bump said their baby cried in pain for the first eight weeks until the switch to NeuroPro Gentlease helped a lot. Another said a gentle Enfamil formula eased immense gas pains. Video reviewers praise Nutramigen's reliability and strict nutrition standards.

What Are the Common Complaints?

Cost leads the list. Nutramigen sells for roughly $50 to $70 per can. A distinct smell also comes up, though most babies adjust when hungry. Some babies see no change, and a few parents dislike corn syrup solids in Gentlease.

Reported drawbacks:

  • High price for Nutramigen
  • Strong smell and taste
  • No improvement for some babies
  • Corn syrup solids in Gentlease
  • Stock gaps on some sizes

How Does Enfamil Colic Relief Formula Compare to Alternatives?

Enfamil's options compete mainly with Similac Alimentum and Gerber Good Start SoothePro. Alimentum is the closest rival to Nutramigen, and guides rate the two equally effective for milk-allergy colic. SoothePro adds the probiotic L. reuteri, which has the strongest colic evidence among probiotics.

FormulaProteinBest for
Enfamil NutramigenExtensively hydrolyzed, LGGColic with milk allergy
Enfamil NeuroPro GentleasePartially hydrolyzedMild fussiness and gas
Similac AlimentumExtensively hydrolyzedColic with milk allergy
Gerber Good Start SootheProPartially hydrolyzed whey, L. reuteriColic and crying

Which Formula Should You Pick?

Pick Nutramigen if your pediatrician suspects a cow's milk allergy. Pick Gentlease for milder gas and fussiness. If two weeks bring no change, go back to your pediatrician. They may suggest a different formula or look for another cause.

Is Enfamil Colic Relief Formula Safe?

Yes, when used as directed. Enfamil formulas are made to meet nutrition standards for infants, and the brand says it is the top pediatrician-recommended name. Mixing instructions matter, so follow the can exactly and never dilute the formula.

Fussiness is not always colic. Fever, vomiting, blood in the stool, poor weight gain, or refusing feeds needs a medical visit, not a formula swap. Switching formula also changes stool color and frequency, which is normal.

Who Should Avoid Enfamil Colic Relief Formula?

Gentlease is not for babies with a confirmed cow's milk allergy, because its protein is only partly broken down. Nutramigen is the allergy-focused choice, and severe cases may need an amino acid formula. Always get a pediatrician's guidance first.

How Much Does Enfamil Colic Relief Formula Cost?

Nutramigen powder costs $50.49 for a 12.6 oz can on Enfamil.com, and $69.99 for the 19.8 oz can. Gentlease is cheaper. Its 32 fl oz ready-to-use bottle lists at $14.49. Prices change, so check the live listing before you order.

ProductSizePrice
Nutramigen powder12.6 oz (357 g) can$50.49
Nutramigen powder19.8 oz (561 g) can$69.99
Gentlease ready to use32 fl oz (946 mL) bottle$14.49

Is Enfamil Colic Relief Formula Worth the Price?

Yes, if it solves a real milk-allergy problem. The 19.8 oz can costs about $0.50 per fl oz against $0.58 for the smaller can, so bigger is cheaper. For mild fussiness, the lower-priced Gentlease is the smarter first try.

Where Can You Buy Enfamil Colic Relief Formula?

Enfamil.com ships free on larger orders. Walmart, Kroger and Albertsons stores, and other grocers also stock it. Buy from trusted sellers only, and check the expiry date on every can.

Is Optimal Weight Plan Worth It for Your Family Routine?

Enfamil's colic formulas are a solid, well-known choice when milk protein is the culprit. They will not fix every crying spell, and your pediatrician should guide the switch.

Here's the thing: sleepless weeks wear parents down. Our coaches at Optimal Weight Plan help busy parents rebuild simple routines around food, movement, and rest, so you can feel strong again.

Ready to feel like yourself? Book a free call with our coaches and start your plan today.

Optimal Weight Plan Coaches
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Optimal Weight Plan Team

The Optimal Weight Plan is a team of experienced health coaches with backgrounds in education, personal health transformations, and OPTAVIA expertise. We provide personalized support and help clients develop sustainable healthy habits. Our coaches combine OPTAVIA program knowledge with a broader "DIY" approach to empower clients to create healthy lifestyles beyond pre-packaged meals.